COVID VACCINE IN DETAILS

MUST KNOW POINTS ABOUT COVID VACCINES AVAILABLE

1.》COVAXIN®

> by Bharat Biotech is developed in collaboration with the Indian Council of Medical Research (ICMR) – National Institute of Virology (NIV).

> Inactivated vaccine

Inactivated vaccines do not replicate and are therefore unlikely to revert and cause pathological effects. They contain dead virus, incapable of infecting people but still able to instruct the immune system to mount a defensive reaction against an infection.

> The vaccine is developed using Whole-Virion Inactivated Vero Cell

> It is a 2-dose vaccination regimen given 28 days apart (im)

> COVAXIN® demonstrated 81% interim efficacy in preventing COVID-19 in those without prior infection after the second dose.

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2.》COVISHIELD™

> ChAdOx1 nCoV- 19 Corona Virus Vaccine – Recombinant vaccine

* The vaccine is a recombinant, replication-deficient chimpanzee adenovirus vector encoding the SARS-CoV-2 Spike (S) glycoprotein –  Genetically modified organism

> Produced in genetically modified human embryonic kidney (HEK) 293 cells.

> (im) Two separate doses of 0.5 ml each. The second dose should be administered between 4 to 6 weeks after the first dose.

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3.》COVID-19 Vaccine AstraZeneca / AZD1222

> manufactured by AstraZeneca

> Recombinant vaccine similar to Covishield: ChAdOx1 nCoV- 19 

> 63 % effective

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4.》Pfizer

Name of Vaccine: BNT162b2, Pfizer-BioNTech COVID-19 Vaccine

Manufacturer: Pfizer, Inc., and BioNTech

Number of Shots: 2 shots, 21 days apart (im)

95% efficacy 

Type of Vaccine: mRNA

Age Indications: 16 years of age and older

*COVID-19 mRNA vaccines give instructions for our cells to make a harmless piece of what is called the “spike protein.”

Once the instructions (mRNA) are inside the immune cells, the cells use them to make the protein piece =》displayed by cells onto cell surface =》triggers immune response 

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5.》Moderna:

Name of Vaccine: Moderna COVID-19 Vaccine / mRNA-1273

Manufacturer: ModernaTx, inc.

Number of Shots: 2 shots, 28 days apart (im)

Type of Vaccine: mRNA

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6.》Janssen 

Name of Vaccine: Janssen COVID-19 Vaccine / JNJ-78436735

Manufacturer: Janssen,  Johnson&Johnson.

Number of Shots: 1 shot (im)

Type of Vaccine: viral vector vaccine 

Age Indications: 18 years of age and older

*Viral vector vaccines use a modified version of a different virus (the vector) to deliver important instructions to our cells.

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7.》Sputnik V

Manufacturer/developer: Gamaleya Research Institute

Research name: Gam-COVID-Vac

Vaccine type: Non-Replicating Viral Vector

Administration method: Intramuscular injection

97.6 % efficacy 

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8.Anticipated vaccination in India;

> BBV154 : intranasal vaccine from Bhatath Biotech

> ZyCoV-D: im/id, plasmid DNA vaccine from Zydus

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BY:-

Dr. Syed Touseef Banu (MD Microbiology)