MUST KNOW POINTS ABOUT COVID VACCINES AVAILABLE
> by Bharat Biotech is developed in collaboration with the Indian Council of Medical Research (ICMR) – National Institute of Virology (NIV).
> Inactivated vaccine
Inactivated vaccines do not replicate and are therefore unlikely to revert and cause pathological effects. They contain dead virus, incapable of infecting people but still able to instruct the immune system to mount a defensive reaction against an infection.
> The vaccine is developed using Whole-Virion Inactivated Vero Cell
> It is a 2-dose vaccination regimen given 28 days apart (im)
> COVAXIN® demonstrated 81% interim efficacy in preventing COVID-19 in those without prior infection after the second dose.
> ChAdOx1 nCoV- 19 Corona Virus Vaccine – Recombinant vaccine
* The vaccine is a recombinant, replication-deficient chimpanzee adenovirus vector encoding the SARS-CoV-2 Spike (S) glycoprotein – Genetically modified organism
> Produced in genetically modified human embryonic kidney (HEK) 293 cells.
> (im) Two separate doses of 0.5 ml each. The second dose should be administered between 4 to 6 weeks after the first dose.
3.》COVID-19 Vaccine AstraZeneca / AZD1222
> manufactured by AstraZeneca
> Recombinant vaccine similar to Covishield: ChAdOx1 nCoV- 19
> 63 % effective
Name of Vaccine: BNT162b2, Pfizer-BioNTech COVID-19 Vaccine
Manufacturer: Pfizer, Inc., and BioNTech
Number of Shots: 2 shots, 21 days apart (im)
Type of Vaccine: mRNA
Age Indications: 16 years of age and older
*COVID-19 mRNA vaccines give instructions for our cells to make a harmless piece of what is called the “spike protein.”
Once the instructions (mRNA) are inside the immune cells, the cells use them to make the protein piece =》displayed by cells onto cell surface =》triggers immune response
Name of Vaccine: Moderna COVID-19 Vaccine / mRNA-1273
Manufacturer: ModernaTx, inc.
Number of Shots: 2 shots, 28 days apart (im)
Type of Vaccine: mRNA
Name of Vaccine: Janssen COVID-19 Vaccine / JNJ-78436735
Manufacturer: Janssen, Johnson&Johnson.
Number of Shots: 1 shot (im)
Type of Vaccine: viral vector vaccine
Age Indications: 18 years of age and older
*Viral vector vaccines use a modified version of a different virus (the vector) to deliver important instructions to our cells.
Manufacturer/developer: Gamaleya Research Institute
Research name: Gam-COVID-Vac
Vaccine type: Non-Replicating Viral Vector
Administration method: Intramuscular injection
97.6 % efficacy
8.Anticipated vaccination in India;
> BBV154 : intranasal vaccine from Bhatath Biotech
> ZyCoV-D: im/id, plasmid DNA vaccine from Zydus
Dr. Syed Touseef Banu (MD Microbiology)