PHARMACOLOGY
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Question 1 of 2
1. Question
1 pointsBuspirone produces anxiolytic effect by acting on the
Correct
Answer (A)
Buspirone is a psychotropic drug with anxiolytic properties which belongs chemically to azaspirodecanediones.
Buspirone shares some of the properties of the benzodiazepines and the neuroleptics, as well as demonstrating other pharmacological action. It is devoid of anticonvulsant and muscle relaxant properties and does not bind to the benzodiazepine/GABA receptor complex. Buspirone has an affinity for brain D(2)-dopamine receptors, where it acts as an antagonist and agonist, and for the 5-HT(1A) receptors, where it acts as an agonist.Incorrect
Answer (A)
Buspirone is a psychotropic drug with anxiolytic properties which belongs chemically to azaspirodecanediones.
Buspirone shares some of the properties of the benzodiazepines and the neuroleptics, as well as demonstrating other pharmacological action. It is devoid of anticonvulsant and muscle relaxant properties and does not bind to the benzodiazepine/GABA receptor complex. Buspirone has an affinity for brain D(2)-dopamine receptors, where it acts as an antagonist and agonist, and for the 5-HT(1A) receptors, where it acts as an agonist. -
Question 2 of 2
2. Question
1 pointsProkinetic drug with no dopamine antagonism:
A. Metoclopramide B. Domperidone
C. Mosapride D. ChloropromazineCorrect
Ans: (C)
Mosapride acts as 5 HT4 agonists and 5 HT3 antagonists.
It does not produce extrapyramidal, hyperprolactinemic side effects due to the absence of D2 blocking property. All other drugs mentioned in the option block the D2 receptors.
Prokinetic Drugs—These are drugs which promote gastrointestinal transit & gastric emptying.
ONDANSETRON – It is 5-HT antagonists. It is used to control cancer chemotherapy/ radiotherapy induced vomiting.Incorrect
Ans: (C)
Mosapride acts as 5 HT4 agonists and 5 HT3 antagonists.
It does not produce extrapyramidal, hyperprolactinemic side effects due to the absence of D2 blocking property. All other drugs mentioned in the option block the D2 receptors.
Prokinetic Drugs—These are drugs which promote gastrointestinal transit & gastric emptying.
ONDANSETRON – It is 5-HT antagonists. It is used to control cancer chemotherapy/ radiotherapy induced vomiting.
